1 TCF 7 L 1 is involved in hypothalamo - pituitary axis development in mice and humans
نویسندگان
چکیده
Carles Gaston-Massuet, Mark J. McCabe, Valeria Scagliotti, Rodrigo M. Young, Gabriela Carreno, Louise C. Gregory, Sujatha A. Jayakody, Sara Pozzi, Angelica Gualtieri, Markella Koniordou, Chun-I Wu, Rodrigo E. Bancalari, Elisa Rahikkala, Riitta Veijola, Tuija Lopponen, Federica Graziola, James Turton, Massimo Signore, Seyedeh Neda Mousavy Gharavy, Nicoletta Charolidi, Cynthia L. Andoniadou, Stephen W. Wilson, Bradley J. Merrill, Mehul T. Dattani and Juan P. Martinez-Barbera
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Spinal and supraspinal analgesic effects of Nimodipine : The role of Hypothalamo-Pituitary-Adrenal(HPA) axis .
Nimodipine, an L-type calcium channel blocker, can induce analgesia. However, it is not clear that this analgesic effect is at the level of spinal or supraspinal pain pathway. In addition, it has been reported that the analgesic effect of nifedipine, another L-type calcium channel blocker is related to the HPA axis, but there is no report indicating the role of this axis in the analgesic eff...
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Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1 (TCF7L1), an important regulator of the WNT/β-catenin signaling pathway, is expressed in the developing forebrain and pituitary gland, but its role during hypothalamo-pituitary (HP) axis formation or involvement in human CH remains elusive...
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The transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis. Heterozygous de novo mutations in SOX2 have previously been associated with bilateral anophthalmia/microphthalmia, developmental delay, short stature, and male genital tract abnormalities. Here we investigated the role of Sox2 in murine pituitary developmen...
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